Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression

PA Beavis; CY Slaney; MH Kershaw; PJ Neeson; PK Darcy

Journal article

Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression

PA Beavis, CY Slaney, MH Kershaw, PJ Neeson, PK Darcy

Immunotherapy | Published : 2015

DOI: 10.2217/imt.15.16

Abstract

Strategies aimed at stimulating the immune system against cancer have signaled a new era for designing new effective therapies for patients. Recent breakthroughs in adoptive cellular therapy and in using checkpoint inhibitors for some patients have renewed much enthusiasm in this field. However, it has become apparent that tumors can use a multitude of inhibitory networks to effectively reduce antitumor immunity. This review discusses our current knowledge of these immune suppressive mechanisms used by tumors and describes potential new strategies that may counteract this problem resulting in significantly increasing therapeutic outcomes of adoptive immunotherapy in a higher proportion of pa..

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University of Melbourne Researchers

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by National Breast Cancer Fellowship

Awarded by NHMRC

Awarded by National Breast Cancer Foundation

Funding Acknowledgements

This work was funded by Program and Project grants from the National Health and Medical Research Council (NHMRC) (Nos. 1013667 and 1030436, respectively). PA Beavis was supported by a National Breast Cancer Fellowship (ID# PF-14-008). PK Darcy and MH Kershaw were supported by NHMRC Senior Research Fellowships (Nos. 1041828 and 1058388, respectively). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.